The two areas where I've had the least success in software investments are educational software and healthcare IT companies, as both sectors are very challenging to reform.

The most successful startups often emerge from addressing broken industries where existing solutions are inadequate.

Many nonprofits lack effective feedback loops and often don't use funds wisely, so I prefer to invest in projects that create tangible value.

It's essential to find a path to implement new ideas, not just identify gaps, especially in industries like healthcare where existing practices may be profitable but inefficient.

When innovating in challenging sectors like healthcare or education, the key is to identify the specific needs that will incentivize stakeholders to adopt your solution.

I believe there is a significant opportunity in addressing health-related issues linked to food consumption, which remains underexplored in the startup world.

Building a startup is challenging, especially in the mental health space, where many investors initially did not prioritize it.

In 2017, I would like to see startups tackle the problem of equality, as we are moving towards a more unequal world. We need to change education and other social systems to address this issue, and I'm also interested in solutions like basic income.

Y Combinator has not seen significant financial success in healthcare, bio, industrials, or real estate, focusing instead on B2B and fintech for future growth.