Big pharma is a business that often prioritizes keeping drugs out of generic status to maintain high prices, which can hinder the discovery of new drugs.

There's a lot of innovation in the biomedical field that isn't covered by patents, which can hinder the development of beneficial treatments. For example, mannose, a sugar that may have potential as an onco-treatment, lacks funding because it cannot be patented.

It's essential to find a path to implement new ideas, not just identify gaps, especially in industries like healthcare where existing practices may be profitable but inefficient.

Insurance companies and pharmacy benefit managers (PBMs) often dictate which medications are authorized, sometimes requiring patients to try cheaper alternatives first, regardless of their effectiveness.

I suspect there are many existing drugs that could be reused in significant ways with minor modifications, and we are very close to discovering something great.

The pharmaceutical industry has a low probability of success, around 10%, which drives the need for AI to improve efficiency in drug discovery and development processes.

The future holds the potential to eradicate diseases, with nonprofits working to identify all human druggable targets to aid the drug industry.

Drug design is complex, with numerous bottlenecks before reaching clinical trials, and we need to innovate in this space to improve the process.

In academia, there is less focus on hardcore drug manufacturing aspects like pharmacokinetics or toxicology, but there is significant interest in molecular glues, machine learning models, and new drug concepts.