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DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
For some participants, the effects of psilocybin lasted for about two to three months before their depression began to return, highlighting the need for integration after the experience.
Video
YC
Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts
@ Y Combinator
03/16/18
Related Takeaways
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
Participants often report that the psilocybin sessions felt more human and connected compared to traditional treatments, emphasizing the importance of the therapeutic relationship. Seventeen out of twenty participants experienced significant improvements in their depression after a single psilocybin session, feeling better for months, but many saw their symptoms return after three months.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
Participants often describe the psilocybin experience as a turbocharged therapy session, where they confront deep-seated issues and emotions that they may have avoided.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
The integration phase after a psychedelic experience is crucial, as it helps participants make sense of their experiences and apply insights to their lives.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
The experience of psilocybin can be intense, often leading to feelings of dying or losing one's ego, which can be both frightening and beautiful for participants.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
Psychedelics like psilocybin can facilitate deep internal change, allowing individuals to understand themselves better and make significant life changes more rapidly than traditional therapies.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
Psychedelics, like psilocybin, can deactivate the part of the brain responsible for negative thinking and rumination, which is particularly beneficial for individuals with depression.
DK
Dr. Karl Deisseroth
05/15/25
@ Andrew Huberman
Psychedelics like LSD and psilocybin can alter reality perception and may help treat depression by increasing brain connectivity and openness to new ideas.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
The preparation for a psilocybin session involves building trust and discussing potential fears, which helps participants feel more comfortable during the experience.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
Our next study will compare the effects of psilocybin with traditional antidepressants, but we have to allocate our limited budget to this new research, which restricts our ability to offer additional sessions to previous participants.