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MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
Before AlphaFold 3, drug designers had to rely on intuition and lengthy lab processes to understand molecular interactions, which is no longer the case.
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The Quest to ‘Solve All Diseases’ with AI: Isomorphic Labs’ Max Jaderberg
@ Sequoia Capital
04/29/25
Related Takeaways
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
AlphaFold 3 allows our drug designers to see how their molecule designs interact with protein targets instantly, which is a game changer in drug design.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
AlphaFold 3 enables drug designers to model not just protein structures but also how these proteins interact with small molecules, enhancing our ability to design effective drugs.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
To achieve transformative drug design, we need several more breakthroughs similar to AlphaFold, focusing on different core concepts of biology and chemistry.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
The first generation of AI applications in drug design often focused on local models, but our approach is to build a more comprehensive system that can generalize across various tasks, as demonstrated by AlphaFold 3, which allows us to create models that generalize across chemistry and target space, enabling application to any protein or small molecule without needing fine-tuning.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
AlphaFold 3 represents a significant breakthrough in understanding biomolecular structure, allowing for experimental-level accuracy in predicting protein structures and their interactions with small molecules, DNA, and RNA.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
The training of AlphaFold 3 involved overcoming challenges in tokenizing various molecular types, including proteins, DNA, and small molecules, to accurately predict their structures and interactions.
DH
Demis Hassabis
05/22/25
@ The Thinking Game Film
Our sister company, Isomorphic Labs, is developing technologies around AlphaFold to design drug compounds that bind to specific parts of protein surfaces, which is crucial for understanding diseases.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
AlphaFold 3 is a significant step towards solving the structure prediction problem, but we still aim for 100% accuracy in understanding molecular interactions.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
Drug design is complex, requiring an understanding of how small molecules interact with proteins, modulating their functions in the body.