Tools
Search
Import
Library
Explore
Videos
Channels
Figures
Atmrix
About
Tools
Search
Import
Library
Explore
Videos
Channels
Figures
Atmrix
About
Go Back
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
The clinical study I was involved in was the first of its kind in the UK, examining psilocybin's effects on 20 people with treatment-resistant depression.
Video
YC
Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts
@ Y Combinator
03/16/18
Related Takeaways
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
This research project on psilocybin started after various studies explored its effects on the brain, particularly focusing on the unconscious mind and how it influences behavior.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
Participants often report that the psilocybin sessions felt more human and connected compared to traditional treatments, emphasizing the importance of the therapeutic relationship. Seventeen out of twenty participants experienced significant improvements in their depression after a single psilocybin session, feeling better for months, but many saw their symptoms return after three months.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
Our next study will compare the effects of psilocybin with traditional antidepressants, but we have to allocate our limited budget to this new research, which restricts our ability to offer additional sessions to previous participants.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
For some participants, the effects of psilocybin lasted for about two to three months before their depression began to return, highlighting the need for integration after the experience.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
Participants often describe the psilocybin experience as a turbocharged therapy session, where they confront deep-seated issues and emotions that they may have avoided.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
The therapeutic bond developed during psilocybin sessions is different from traditional therapy, as it fosters a more human and equal relationship between participants and guides.
DK
Dr. Karl Deisseroth
05/15/25
@ Andrew Huberman
Psychedelics like LSD and psilocybin can alter reality perception and may help treat depression by increasing brain connectivity and openness to new ideas.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
Psychedelics like psilocybin can facilitate deep internal change, allowing individuals to understand themselves better and make significant life changes more rapidly than traditional therapies.
DR
Dr. Rosalind Watts
03/16/18
@ Y Combinator
Participants in the study had an average of 18 years of depression and had tried between 3 and 11 different types of antidepressants without success.