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AH

Andrew Huberman

05/28/25

@ Theo Von

The better something feels, the lower you will feel afterwards, and it takes longer to return to your baseline dopamine levels.

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Andrew Huberman | This Past Weekend w/ Theo Von #585

@ Theo Von

Andrew Huberman | This Past Weekend w/ Theo Von #585

05/28/25

Related Takeaways

AH

Andrew Huberman

05/28/25

@ Theo Von

Dopamine raises your baseline level, boosting your confidence, but it also raises the threshold for experiencing dopamine, making it harder to feel the same joy from previous experiences.

RS

Ryan Soave

04/21/25

@ Andrew Huberman

The dopamine dynamics show that quick inflections in dopamine lead to diminishing returns, causing people to chase feelings that no longer provide satisfaction.

DA

Dr. Anna Lembke

08/16/21

@ Andrew Huberman

We are always releasing dopamine at a tonic baseline rate, and deviations from this baseline are what influence our experience of pleasure and pain.

DA

Dr. Anna Lembke

08/16/21

@ Andrew Huberman

Chronic exposure to substances or behaviors that release large amounts of dopamine can lower our tonic baseline over time, leading to a dopamine deficit state.

AH

Andrew Huberman

01/03/22

@ Andrew Huberman

When you anticipate a reward and it arrives, the associated behavior is more likely to occur again; however, if the expected reward does not come, dopamine levels can drop significantly.

DA

Dr. Anna Lembke

08/16/21

@ Andrew Huberman

When we indulge in pleasurable activities, our brain compensates by down-regulating dopamine receptors, which can lead to a state of anhedonia if indulged repeatedly.

AH

Andrew Huberman

01/30/25

@ Andrew Huberman

Extending the positive phase of dopamine release while blunting the pain response can lead to greater happiness and motivation in pursuing long-term goals.

AH

Andrew Huberman

06/19/25

@ Andrew Huberman

Low levels of dopamine and serotonin can lead to anhedonia, making it difficult to experience pleasure, which is why treatments like antidepressants aim to raise these baseline levels.

AH

Andrew Huberman

10/07/20

@ Lewis Howes

Dopamine is released when we pursue our goals, which is why many people feel depressed after achieving a big goal; they expect a greater reward.