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MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
Understanding how molecules interact with all proteins in the body is crucial, as this knowledge can help predict toxicity and improve drug design.
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The Quest to ‘Solve All Diseases’ with AI: Isomorphic Labs’ Max Jaderberg
@ Sequoia Capital
04/29/25
Related Takeaways
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
Drug design is complex, requiring an understanding of how small molecules interact with proteins, modulating their functions in the body.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
AlphaFold 3 enables drug designers to model not just protein structures but also how these proteins interact with small molecules, enhancing our ability to design effective drugs.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
Before AlphaFold 3, drug designers had to rely on intuition and lengthy lab processes to understand molecular interactions, which is no longer the case.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
There's a significant opportunity in generating in vivo data, which is currently limited, to better understand drug interactions in real biological systems, and we're seeing breakthroughs in data-generating technology in biology and chemistry that will significantly impact how we model these fields.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
AlphaFold 3 allows our drug designers to see how their molecule designs interact with protein targets instantly, which is a game changer in drug design.
PH
Patrick Hsu
04/15/25
@ Sequoia Capital
Programming biology goes beyond drug development; it involves understanding how hormones can influence thoughts, feelings, and behaviors in powerful ways.
PH
Patrick Hsu
04/15/25
@ Sequoia Capital
Machine learning for biology is not limited to drug design; it encompasses a broader potential that significantly impacts human lives.
MJ
Max Jaderberg
04/29/25
@ Sequoia Capital
Generative models are essential for navigating the vast molecular space, allowing us to explore potential designs that could lead to effective therapeutics.
PH
Patrick Hsu
04/15/25
@ Sequoia Capital
The model can also predict the next amino acid residue, which is crucial for determining the functionality of enzymes in biological processes.