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Dr. Anna Lembke

08/16/21

@ Andrew Huberman

The balance between pleasure and pain in the brain is maintained by the same neural pathways, and any deviation from neutrality prompts the brain to restore balance.

Video

Dr. Anna Lembke: Understanding & Treating Addiction

@ Andrew Huberman

Dr. Anna Lembke: Understanding & Treating Addiction

08/16/21

Related Takeaways

Andrew Huberman

06/19/25

@ Andrew Huberman

The brain interprets electrical signals from sensory neurons, creating experiences of pleasure and pain based on both innate and learned factors.

Andrew Huberman

06/19/25

@ Andrew Huberman

Understanding the interaction between pleasure and pain, along with the underlying biological systems, is essential for managing our subjective experiences of these sensations.

Andrew Huberman

06/19/25

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Pain and pleasure are sensations that reflect opposite ends of a continuum, involving detection through our skin and interpretation by our brain.

Dr. Anna Lembke

08/16/21

@ Andrew Huberman

Understanding the balance of pleasure and pain is crucial for managing addiction and improving our overall well-being.

Dr. Anna Lembke

08/16/21

@ Andrew Huberman

We are always releasing dopamine at a tonic baseline rate, and deviations from this baseline are what influence our experience of pleasure and pain.

Dr. Anna Lembke

08/16/21

@ Andrew Huberman

When we indulge in pleasurable activities, our brain compensates by down-regulating dopamine receptors, which can lead to a state of anhedonia if indulged repeatedly.

Andrew Huberman

06/19/25

@ Andrew Huberman

Pleasure is a sensation that encourages us to pursue more of what brings it, while pain prompts us to withdraw from harmful activities.

Dr. Anna Lembke

08/16/21

@ Andrew Huberman

To maintain a healthy dopamine balance, we should avoid overindulgence and allow ourselves to experience some boredom and discomfort.

Andrew Huberman

05/28/25

@ Theo Von

The brain is incredibly plastic from ages 0 to 25, meaning experiences can significantly modify its wiring, impacting behaviors and expectations around pleasure.