Second-time founders often feel pressure to come up with a genius idea, but the best startups usually succeed by simply doing something better than existing options.

Many companies focus on small problems, but the most interesting innovations address fundamental human needs and behaviors.

As an investor, I'm particularly interested in great ideas that I haven't thought of yet, especially in networks and marketplaces, which I know well. A great entrepreneur often has a fascinating idea that can scale to millions or hundreds of millions of people, positively impacting lives and changing the human ecosystem.

Drug companies are incentivized to find new uses for existing drugs rather than discover new ones, which is a serious problem in the pharmaceutical industry.

I'm not limiting myself to good ideas; many of my ideas are not good, but this is relevant to startups because often good ideas look bad initially.

I suspect there are many existing drugs that could be reused in significant ways with minor modifications, and we are very close to discovering something great.

Creativity often involves a new combination of existing ideas presented in a novel way, rather than entirely new concepts.

I prefer to engage in startup ideas only when there's a concrete concept, as this allows for efficient validation and execution, contrary to the common advice of exploring many alternatives.

Using existing technology and modifying it can lead to innovative solutions, as seen with companies that repurpose off-the-shelf products for new applications.