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MW

Matthew Walker

05/01/25

@ Peter H. Diamandis

DORA drugs work by gently reducing wakefulness rather than knocking you out, allowing for a more natural sleep experience.

Video

PH

Sleep Scientist: This Is What Poor Sleep Really Does to Your Body and Brain w/ Matt Walker | #167

@ Peter H. Diamandis

Sleep Scientist: This Is What Poor Sleep Really Does to Your Body and Brain w/ Matt Walker | #167

05/01/25

Related Takeaways

MW

Matthew Walker

05/01/25

@ Peter H. Diamandis

Studies show that DORA medications not only increase total sleep time but also improve the clearance of Alzheimer's-related proteins from the brain.

MW

Matthew Walker

05/01/25

@ Peter H. Diamandis

I've publicly advocated for a new class of sleep medications called DORAs, which promote naturalistic sleep rather than sedation.

AH

Andrew Huberman

08/08/22

@ Andrew Huberman

Digital tools, such as non-sleep deep rest scripts and self-hypnosis, can enhance your ability to fall and stay asleep, providing zero-cost options for better sleep.

MW

Matthew Walker

05/01/25

@ Peter H. Diamandis

Sedation is not the same as sleep; true restorative rest requires a rhythm, routine, and proper wind-down techniques.

MW

Matthew Walker

04/17/24

@ Andrew Huberman

Delaying caffeine intake after waking can help clear adenosine, which builds up during sleep, rather than blocking adenosine receptors immediately with caffeine.

MW

Matthew Walker

05/01/25

@ Peter H. Diamandis

Sleep aids should not be viewed as a quick fix; understanding sleep quality versus mere sedation is crucial for effective sleep management.

AH

Andrew Huberman

08/08/22

@ Andrew Huberman

Delay caffeine intake for 90 to 120 minutes after waking to clear residual adenosine and avoid an afternoon crash.

AH

Andrew Huberman

05/08/25

@ Andrew Huberman

Low-frequency sounds, like delta waves, can aid in transitioning to sleep, while higher frequencies, like beta waves, are beneficial for focus and sustained thought.

MW

Matthew Walker

04/17/24

@ Andrew Huberman

A 20-minute nap can enhance alertness and concentration without causing sleep inertia, which is the grogginess some people feel after longer naps.