ATP is essential for any activity that requires energy, and our muscles and neurons utilize different fuel sources to generate ATP, including phosphocreatine for short, intense efforts and glucose for longer durations.

Dopamine release in response to recognizing achievements can counteract fatigue and enhance performance, allowing you to push through physical and mental challenges.

The adaptations from anaerobic endurance training include improved mitochondrial respiration, allowing for greater energy generation through oxygen utilization, which significantly benefits various types of exercise, including competitive sports and activities requiring bursts of effort.

Training to failure can lead to greater muscle growth but also increases fatigue significantly, so it's important to balance intensity and recovery. Going from some number of reps in reserve all the way to failure in a single mesocycle is a good practice for many, but not required; you can go two or three reps in reserve as long as you do enough sets to achieve close to ideal hypertrophy outcomes.

Exercise is essential for improving mitochondrial health, as it increases the number and function of mitochondria, which are crucial for energy production in muscles.

Combining strength and endurance training throughout the week is beneficial for brain-derived neurotrophic factor and reducing inflammation.

Engaging in difficult tasks can help maintain brain circuitry, allowing for greater cognitive vigor as we age.

The ability to push through discomfort and pain points can be applied to various aspects of life, as the same neurochemicals are involved in different challenges.

Building capillary beds through long-duration efforts increases oxygen availability to muscles, which is crucial for endurance performance.